Ayala was born in Bukidnon, a province in the southern Philippines known for its diverse indigenous cultures. His parents, Joe and Tita, were both writers and painters who played music in the home all day long. Growing up surrounded by music and art, Joey developed an intuitive understanding of art at an early age. This upbringing would later influence his musical style and thematic content.

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In the 1980s, Ayala emerged as a leading figure in the Philippine music scene during a period of social and political upheaval. His songs often addressed pressing issues such as environmental conservation, indigenous rights, social justice, and national identity. With his distinct voice and innovative musical arrangements, he captured the attention of audiences across the country and quickly gained a loyal following.

One of Ayala's most significant contributions to Filipino music is his incorporation of traditional indigenous instruments into his compositions. He skillfully integrates instruments like the kubing (bamboo mouth harp), kulintang (gong ensemble), and hegalong (two-stringed lute) into his songs, creating a sound that is both modern and deeply rooted in Filipino heritage.

Throughout his career, Ayala has released numerous albums, each showcasing his versatility as a musician and his commitment to promoting Filipino culture. Some of his most popular songs include "Magkabilaan," "Karaniwang Tao," and "Walang Hanggang Paalam," which have become anthems for social and environmental advocacy in the Philippines.In addition to his musical endeavors, Ayala is also a passionate advocate for indigenous rights, environmental conservation, and purposeful living. He has been actively involved in various initiatives aimed at preserving indigenous cultures and protecting the environment, using his platform as a musician to raise awareness about these important issues.

Ayala's influence extends beyond the realm of music. He is also a sought-after speaker and educator, often participating in workshops, lectures, and cultural exchanges both in the Philippines and abroad. Using a variety of art-infused “mental tools” he leads workshop participants to the formulation of life goals and project plans without the associated “nose-bleed”. Through his work, he seeks to inspire others to embrace their cultural heritage and take action to create positive change in their communities.

Today, Joey Ayala continues to be a prominent figure in Filipino music and culture. His songs remain relevant and impactful, resonating with audiences of all ages and backgrounds. As a musician, cultural advocate, and social activist, he has left an indelible mark on the Filipino cultural landscape, earning him a place as one of the country's most beloved and respected artists.